Understanding Your Polygenic Risk Reports

Understanding Your Polygenic Risk Reports

Polygenic risk reports are innovative reports that examine hundreds and in some cases thousands, of variants across the genome to provide a comprehensive genetic risk estimate based on a method called polygenic risk scores (PRS).

The three initial Polygenic Risk Reports available are based on studies of European populations, so they are only available for people who are mainly of European ancestry.

To view any of your polygenic risk reports, click on one of the polygenic conditions listed in the summary.

Click on each condition to view your personalized report
Click on each condition to view your personalized report

In this example, the user has a slightly increased risk of developing heart disease. Clicking on this condition will open the full report for heart disease.

A sample report indicating slightly increased genetic risk for heart disease
A sample report indicating slightly increased genetic risk for heart disease

The page includes a population infographic that compares your genetic risk score for developing heart disease with the risk among people your age and of your biological sex in the general population. Click the tabs “People like you” and “General population” to toggle between them.

Understanding your lifetime risk
Understanding your lifetime risk

The remainder of the page provides more information on next steps, offering suggestions on ways to manage your lifestyle, gain more knowledge about a particular condition, find out about recommended screenings, or help empower additional family members to find out their genetic risk.

Explore next steps
Explore next steps

Other risk factors

Genetics has a strong influence on your risk of developing certain conditions, but your risk is also affected by your lifestyle and environment. All of the genetic risk reports include a tab labeled “Other risk factors” that details the other factors that can impact your risk for developing a genetic disease.

Explore other risk factors
Explore other risk factors

About the condition

In the third tab of your customized report, labeled “About the condition,” you’ll receive more detailed information regarding the specific condition, including symptoms, frequency, genetic factors, and lifestyle considerations.

Report details

In the fourth and final tab of your report, “Report details,” you’ll find out more about how your genetic risk estimate was determined.

You’ll also find a list of test considerations that are important for you to keep in mind and that you can share with your healthcare provider.

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